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The US Food and Drug Administration (FDA) has notified healthcare professionals and patients that the antidepressant Celexa (citalopram hydrobromide) should no longer be used at doses greater than 40mg per day because it can cause abnormal changes in the electrical activity of the heart.
Studies have shown no benefit in the treatment of depression at doses higher than 40mg per day. Previously, the citalopram drug label stated that certain patients may require a dose of 60mg per day.
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The citalopram drug label has been revised to include the new drug dosage and usage recommendations, as well as information about the potential for QT interval prolongation and Torsade de Pointes.
