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Published on 11 April 2011

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Drug combination beats obesity

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A combination of two drugs has twice the slimming power of the leading anti-obesity pill orlistat, trial results have shown.

It also has other health benefits, including lowering blood pressure and levels of harmful fatty molecules and sugar in the blood.

Researchers tested the two drugs phentermine and topiramate on almost 2,500 overweight and obese adults from 93 US centres.

Patients were split into groups who received a 56-week course of treatment with different doses of the drugs or a ‘dummy’ placebo.

The results of the ‘Conquer’ Phase III trial were published today in an early online edition of The Lancet medical journal.

They showed that patients taking the drugs in higher doses lost 10.2 kilograms, or 22 pounds, on average.

Overall, 70% of patients in the higher dose group achieved 5% weight loss. This compared with 21% of those in the placebo group, and 62% of those taking the lower dose.

The combination was more effective than orlistat, currently the only anti-obesity drug available on the NHS.

In some diabetic patients, it achieved more than double the weight loss seen after up to four years treatment with orlistat.

The scientists, led by Dr Kishore Gadde, from Duke University Medical Centre in Durham, US, wrote: “Most importantly, weight loss achieved with phentermine and topiramate was sustained during 56 weeks with improvements in blood pressure, lipids (blood fats), glycaemia (blood sugar) and inflammatory markers.

“The combination of phentermine and topiramate, with office-based lifestyle interventions, might be a valuable treatment for obesity that can be provided by family doctors.”

Copyright © Press Association 2011



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