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Published on 6 February 2007

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Dependency risks with tramadol

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Tramadol withdrawal reactions may be a bigger problem than previously thought, the Swedish Medical Products Agency has announced. The Swedish adverse reactions database (SWEDIS) contains 71 reports of abstinence/withdrawal symptoms with tramadol (a drug that is prescribed for moderate to severe pain), 25 of which were also classed as dependence, habituation or increased tolerance. Treatment duration ranged from one week to more than three years, at dosages of 50–2,999mg, showing that withdrawal symptoms have been reported in low/normal doses, and after treatment periods of less than six months.



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