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NicOx and TOPIGEN Pharmaceuticals terminate collaboration


NicOx S.A. today announced that NicOx and TOPIGEN Pharmaceuticals Inc. have mutually terminated their collaboration for TPI 1020.

This decision was made as a result of the acquisition of TOPIGEN by Pharmaxis announced yesterday.

Following two phase 2a studies that were conducted by TOPIGEN with TPI 1020 in patients with asthma and COPD, NicOx and TOPIGEN had recently been in active discussions to explore potential new opportunities for the development of TPI 1020 in a variety of respiratory indications. As a result of the strategic review of Pharmaxis and TOPIGEN’s development pipeline, they have decided not to move forward with the development of TPI 1020.

The licensing and co-development agreement between NicOx and TOPIGEN on TPI 1020, a novel anti-inflammatory drug-candidate for respiratory indications, was signed in October 2005.

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