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Published on 16 June 2014

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Poorly soluble drugs workshop

The second APGI Poorly Soluble Drugs Workshop will be held on 2 July 2014 in Lille, France.
It will be dedicated to the appropriate formulation of poorly water-soluble drugs. During the 1-day event, oral and poster presentations from academia and industry, practical demonstrations (in small groups) and an industrial exhibition are planned.

The second APGI Poorly Soluble Drugs Workshop will be held on 2 July 2014 in Lille, France.
It will be dedicated to the appropriate formulation of poorly water-soluble drugs. During the 1-day event, oral and poster presentations from academia and industry, practical demonstrations (in small groups) and an industrial exhibition are planned.
One of the major challenges encountered in the development of innovative drug products is the poor water-solubility of most newly identified drug candidates. The use of conventional pharmaceutical dosage forms does not allow for sufficient drug dissolution in the human body and, thus, leads to very low concentrations at the site of action (poor bioavailability). Consequently, even compounds offering ideal chemical structures to interact with their target sites fail in vivo.
To overcome this restriction, various strategies have been proposed, e.g. the poorly water-soluble compounds can be molecularly dispersed within hydrophilic matrices, be provided in an amorphous state, combined with surfactants, cyclodextrines and/or their particle size might be reduced into the nanometer range. This workshop will give an update on the current state of the art of how to best formulate poorly water-soluble drugs. An overview on the available excipients, preparation techniques and apparatuses, characterization methods and future strategies will be given by worldwide leading experts in the field.
The entire spectrum, ranging from engineering aspects during the manufacturing process, the portfolio of commercially available excipients able to increase apparent drug solubility and/or to stabilize the systems during long-term storage, the underlying drug-release mechanisms and physical principles, characterization methods for the major properties of the devices and potential pitfalls and hurdles to be overcome during product development will be addressed.
As practical demonstrations are included, the maximum number of participants is limited to 150.
The workshop, organised by the Association de Pharmacie Galénique Industirelle – International Society of Drug Delivery Sciences and Technology (AGPI) will be held at the University of Lille, College of Pharmacy, 3 Rue du Professeur Laguesse, 59006 Lille, France.

 



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