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Published on 18 August 2010

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Shire news alert


Shire plc, the global specialty biopharmaceutical company, announces that on August 17, 2010, it was notified by Ms Barbara Deptula, a Person Discharging Managerial Responsibility, of the exercise, on August 16, 2010, of Stock Appreciation Rights over 13,334 Shire American Depositary Shares (“ADSs”) at an exercise price of $49.36, resulting in 3,795 ADSs being released.

The Company was also notified by Ms Deptula on August 17, 2010 of the following sale of ADSs and Shire plc ordinary shares of 5p each (“Shares”).

Date of Sale       Number of ADSs sold    Number of Shares sold    Sale Price

August 16, 2010 3,795                          –                                   $69.00

August 13, 2010 13,317                        –                                   $68.816

August 13, 2010 1,300                          –                                   $68.910

August 13, 2010 2,437                          –                                   $68.76

August 13, 2010  –                               21,617                        £14.767573

Following the above transactions, Ms Deptula holds awards of Stock Appreciation Rights, Performance Shares and Restricted Shares over 81,797 ADSs. One ADS equals 3 Shares.


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