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Published on 8 June 2009

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Victoza more effective at lowering blood sugar

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Data presented today at the 69th Annual Scientific Sessions of the American Diabetes Association (ADA) showed that once-daily Victoza, taken as monotherapy, leads to statistically significant and sustained reductions in blood sugar and weight after two years of treatment.

In the study, 53% of patients treated with Victoza 1.2 mg once daily reached and maintained the ADA’s blood sugar target of HbA1C less than 7% versus 37% of patients treated with glimepiride 8 mg once daily.

“The fact that Victoza continues to effectively lower blood sugar after two years of treatment is consistent with its other long-term clinical benefits such as continued reductions in fasting blood sugar and weight,” said Dr Alan Garber, Baylor College of Medicine, Houston, a LEAD 3 principal study investigator.

“Even with available treatments, many type 2 diabetes patients still struggle to control their blood sugar, while losing weight. Victoza represents an important advance for these patients.”
The LEAD 3 extension study also documented that treatment with Victoza leads to early and lasting weight loss.

Many currently available diabetes treatments lead to weight gain, a concern for type 2 diabetes patients, most of whom are already overweight.  After two years of treatment with 1.2 mg of Victoza, mean body weight decreased significantly (-2.1 kg) compared to an overall weight increase in the glimepiride group (+1.1 kg).

Minor hypoglycaemia was more than six times less frequent in the Victoza  treatment groups compared with the glimepiride group. Hypoglycaemia is a condition where blood sugar levels become too low.

Viggo Birch, Managing Director, Novo Nordisk UK and Ireland commented “These new data are extremely positive and bring us closer to being able to provide a new treatment option for type 2 diabetes patients that not only enables them to control their blood sugar, but can also lead to weight loss.



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