This site is intended for health professionals only!

Published on 22 September 2008

Share this story:
Twitter
LinkedIn

New drug to battle MRSA superbugs

teaser

The fight against hospital superbugs has been stepped up with the study of the oral antibiotic EDP-322, a first-in-class MRSA-active bicyclolide.

The novel macrolide-related drug has a distinct resistance profile, and the clinical development program will include the treatment of hospital and community-acquired gram-positive infections.

Enanta Pharmaceuticals said that EDP-322 has demonstrated strong in-vitro activity against hospital-acquired MRSA strains resistant to Vancomycin, Zyvox (linezolid), and Cubican (daptomycin).

Robert Moellering, a professor of medicine at Harvard Medical School and Beth Israel Deaconess Medical Center said: “Macrolides have been commonly prescribed to treat community infections for decades due to their convenient oral dosing and favourable safety profile.

“Now, with the discovery of a new generation of macrolides having high potency against hospital-acquired pathogens and a distinct resistance profile relative to other hospital antibiotics, there is a tremendous new opportunity to explore their use within not only the community, but the hospital setting as well.”

Enanta spokesman Yat Sun Or said, “In our in-vitro studies, EDP-322 demonstrated good potency against both hospital and community acquired MRSA, even against highly drug-resistant MRSA strains. The potency of EDP-322 against gram-positive pathogens has the potential to uniquely position EDP-322 among marketed MRSA drugs.”

Copyright PA Business 2008

Enanta Pharmaceuticals



Most read




Latest Issue

Be in the know
Subscribe to Hospital Pharmacy Europe newsletter and magazine
Share this story:
Twitter
LinkedIn