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Connexios present preclinical data on CNX-011-67


Connexios Life Sciences, a research and development company focused on developing novel therapeutics for metabolic disorders, today announced that preclinical data on CNX-011-67, a highly potent and selective GPR40 agonist, was presented at the 71st Scientific Sessions of the American Diabetes Association taking place from 24 – 28 June 2011 at San Diego, California.

CNX-011-67 is a novel small molecule candidate that, by acting on the pancreatic beta cells, will enhance glucose sensitivity, insulin secretion and reduce metabolic stress.

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The data presented in the meeting adds to the growing understanding of the critical role played by GPR40 for the health and function of the pancreatic beta cell. The two-pronged impact of GPR40 activation by CNX-011-67 simultaneously enhances insulin content and glucose-stimulated insulin secretion, while significantly reducing metabolic stress in the beta cell and consequent apoptosis.

CNX-011-67 is being developed by Connexios as an oral anti-diabetic that can potentially be positioned as a key early therapy for diabetics, protecting against beta cell decline and delaying the onset or progression of disease, while providing robust glycemic control.

Connexios Life Sciences

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