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A meta-analysis comparing enoxaparin with unfractionated heparin (UFH) in all acute coronary syndromes (ACS) concludes that overall, enoxaparin gives better outcomes: a higher incidence of major bleeding is outweighed by fewer serious cardiovascular events.
The authors note that while anti-thrombin therapy is an established central treatment in ACS, it is still unclear which drug gives best results overall. There is considerable trial data available for the low-molecular-weight heparin enoxaparin, and the aim of this analysis was to determine whether this is associated with a better balance of risk and safety than UFH.
The authors carried out a literature search for controlled trials comparing enoxaparin with UFH in patients with ACS