Oxytocin (Syntocinon®) and ergometrine with oxytocin (Syntometrine®) are two well-known brands of oxytocics in current use in maternity centres within the UK.
It is common practice to refer to these drugs by their brand names. A subsequent shortening of Syntocinon® to ‘Synto’ in verbal communication has led to inadvertent administration of the wrong product.
As a generic brand of oxytocin is now also readily available, it is quite possible for staff to select Syntometrine from the fridge when ‘Synto’ is requested as this is the only product that resembles this name. This risk is likely to further increase as new members of staff, unfamiliar with the Syntocinon® brand of oxytocin, commence practice.
Likewise, referring to the combination product by its generic name (ergometrine and oxytocin), or vice versa runs the risk of it being mistaken as just one or other of the ingredients rather than the combination product.
The National Reporting and Learning System (NRLS) reported 1157 patient safety incidences over a five year period (2013-2018) involving Syntocinon® or Syntometrine®. Of these, 39 incidences resulted in the incorrect drug being given. Discussion with colleagues working within maternity centres has identified near misses and actual errors possibly resulting from the terminology being used. Staff working under pressure may inadvertently confuse the two products or misread the drug name due to the historical practice of using the prefix ‘Synto’ for both products.
The UKCPA Women’s Health Group recommend the following:
All centres to stop using the terms ‘Synto’ and ‘Syntocinon®’. Oxytocin must be referred to only by its generic name.
All centres to refer to the combination product as ‘Syntometrine®’.
All health professionals referring to these drugs as ‘Synto’ be challenged by colleagues and clarification sought regarding which drug is intended before administration.
All education facilities going forward refrain from using terminology other than that proposed in this paper.
In time, it is hoped that with concerted efforts, the term ‘Synto’ will no longer be used and that this will result in the reduction of medication errors.
These recommendations have been endorsed by the Royal College of Nursing and the Royal Pharmaceutical Society, and supported by the Royal College of Anaesthetists.
Robbie Turner, Director of Pharmacy and Member Experience at the Royal Pharmaceutical Society, says “The RPS welcomes the UKCPA Women’s Health Group advisory paper ‘Syntocinon® & Syntometrine®: Rephrasing terminology to avoid errors’. Evidence shows there’s been a large number of errors involving Syntocinon® or Syntometrine®, which makes these recommendations very timely. Implementing the advice should help reduce preventable medication errors and improve patient safety.”
The recommendations have been developed by Christina Nurmahi (Chair of UKCPA Women’s Health Group), Lead Pharmacist for Women and Newborn at University Hospital Southampton NHS Foundation Trust, Elaine Smith, Lead Pharmacist for Women and Children at Chelsea and Westminster Hospital NHS Trust, and Dr Nuttan Tanna, Pharmacist Consultant, Women’s Health & Osteoporosis / Bone Health at London North West University Healthcare NHS Trust.